Correlation analysis of the clinicopathological features of glioma and expression of p53 and VEGF

Glioma is a common type of brain and neurological cancer with high degree of malignancy. Expression of p53 has been found in a variety of tumor cells and VEGF has been associated with the angiogenesis in cancers. In this study, the expressions of p53 and VEGF in glioma were examined. The relationship between clinicopathological features of glioma and the expression profiles of p53 and VEGF was analyzed. Levels of p53 and VEGF in the serum of glioma patients were detected by ELISA. Immunohistochemical staining was used to measure the protein expressions of p53 and VEGF. The correlation between the changes of p53 and VEGF and clinical pathological features of glioma was analyzed. The expression levels of P53 and VEGF in glioma group were significantly higher than that in the control group before surgery. The expression levels of P53 and VEGF in glioma group were significantly reduced after surgery, compared with those before surgery (P < 0.05). In glioma group, p53 positive rate was 73.3% and VEGF positive rate was 76.7%, which were significantly higher than that in adjacent normal tissues or control group (P < 0.05). Expression of p53 was positively correlated with the expression of VEGF (P < 0.05). The expression levels of P53 and VEGF were correlated with pathological type of glioma, WHO classification, distant metastasis, and survival time (P < 0.05), but not age, sex, or PS score (P > 0.05). The expression levels of P53 and VEGF were up-regulated in both the serum and tumor tissues of glioma patients. The expression levels of P53 and VEGF were correlated with the pathological type of glioma, WHO classification, distant metastasis, and survival time, suggesting they might play a pivotal role in the development of glioma.